Antimicrobial susceptibility patterns of the gram-negative bacteria isolated from septicemia in Children's Medical Center, Tehran, Iran
نویسندگان
چکیده
INTRODUCTION The choice of antimicrobial treatment for septicemia is often empirical and based on the knowledge of local anti-microbial activity patterns of the most common bacteria causing such bloodstream infections. The current study aimed to study the prevalence of bacterial pathogens causing septicemia and their antimicrobial resistant profiles in hospital admitted patients. METHODS This cross sectional study done at Children's Medical Center, Tehran, Iran. We examined 168 bacterial strains isolated from 186 clinically diagnosed septicemia cases refereed at Children's Medical Center, Tehran, Iran. Over a period of twelve months from July 2010 to 2011 July. 11446 blood samples from patients of clinically suggestive septicemia were evaluated. RESULTS Bacterial strains were isolated from 910 (7.95%) of blood cultures. Gram-negative bacteria identified were Pseudomonas species (20.5%), Pseudomonas aeruginosa (1.86%), Salmonella spp (1.09%), Acinetobacter naumannii (8.13%), Escherichia coli (4.06%), Klebsiella spp (5.16%). Gram-negative pathogens were more than gram positive in bloodstream infections. Antimicrobial susceptibility testing was done according to Clinical and Laboratory Standards Institute (CLSI, USA) guidelines against: amikacin ampicillin, amoxicillin, amoxiclav, cefuroxime, cefotaxime, ceftazidime, cefoperazone tetracycline, chloramphenicol, ciprofloxacin, gentamicin. Resistanc to different antibiotics in the most important isolated bacteria were: 32.1%, 10.8%, 87.8%, 96%, 39.1%, 35.2, 49.4%, 69%, 80.02%, 22%, 59%, 30.1% respectively, for Pseudomonas spp, 32%, 3.7%, 84.2%, 83.2%, 80.1%, 75.4%, 44.8%, 45.2%, 33.3%, 19%, 34.1, 11.5% respectively for Acinetobacter species. DISCUSSION Resistant to majority of the antimicrobial agents for several pathogens implicated in bloodstream infections, particularly in Gram-negative bacteria, can make complication in treatment of infection cause by them.
منابع مشابه
Antimicrobial Susceptibility of Bacterial Agent in Hospitalized Neonates in Intensive Care Unit in Bahrami Hospital of Tehran, Iran
Abstract Background and Objective: This study aimed to investigate the antimicrobial susceptibility of the most common pathogens in hospitalized neonates in Intensive Care Unit. Material and Methods: In this one-year descriptive study, 150 blood samples of neonates in Intensive Care Unit of Bahrami hospital of Tehran were divided into two groups of early onset sepsis (the first 72 hours...
متن کاملFrequency of Pathogens and Antimicrobial Susceptibility of Bacteria Isolated from Bloodstream Infections
Background and Objectives: Blood stream infections cause significant morbidity and mortality in the world. In this study, we aimed at describing the organisms responsible for septicemia in 2006-2007 and their antimicrobial susceptibility that might lead to proper selection of antimicrobial agents in hospitalized patients with suspected sepsis. Materials and Methods: Microbiology reports of ...
متن کاملType of Bacterial Isolates and Antibiotic Resistance Patterns from Clinical Specimens in Yazd, Iran
Background and Aims: Due to a wide variety of causes, various bacteria can acquire resistance to antibiotics. This study investigated the antibiotic susceptibility patterns of the etiologic bacterial agents of various infections in patients referred to three hospitals in Yazd city, Iran. Materials and Methods: A total of 336 clinical specimens including wound discharge, sputum, blood, bronchia...
متن کاملMultidrug resistance pattern of bacterial agents isolated from patient with chronic sinusitis
Background: Treatment of chronic sinusitis is complicated due to increase of antibiotic-resistant bacteria. The aim of this study was to determine the multidrug resistance (MDR) pattern of the bacteria causing chronic sinusitis in north of Iran. Methods: This cross-sectional study was carried out on patients with chronic sinusitis. Bacterial susceptibility to antimicrobial agents was determi...
متن کاملDetermination of Frequency of Positive Blood Culture Samples and Antibiotic Resistance Pattern of Isolated Bacteria from Patients Suspected of Infectious Diseases Admitted to Imam Khomeini Hospital in Ahvaz in 2013-2016
Introduction: The invasion of microorganisms into the bloodstream and spread to different parts of body can cause disruption the functions of vital organs and even death. This study aimed to evaluation of positive blood cultures in patients suspected to septicemia admitted to the Imam Khomeini Hospital in 2013-2016. Materials and Methods: In this study, blood samples of patients were cultured ...
متن کامل